Safety and Efficacy of 48-Week, Long-Term Administration of D-Allulose in Patients with High LDL-Cholesterol Levels
Allulose StoreMisuzu Tanaka, Akane Kanasaki, Noriko
Hayashi, Tetsuo Iida, Koji MuraMisuzu Tanaka, Akane Kanasaki, Noriko
Hayashi, Tetsuo Iida, Koji Muraoo
Source: JSTAGE 2020.
Abstract
D-allulose is one of the rare sugars that contains almost zero calories and provides various health benefits.
Previous studies have reported the safety of D-allulose in normal, overweight/obese, and diabetic individuals.
However, one study reported significant increases in T-Cho and LDL-C after 12 weeks of D-allulose intake; this report was not a randomized controlled trial and attributed these changes to seasonal variation.
Therefore, we conducted a randomized, double-blind, placebo-controlled trial in 90 subjects with high LDL-cholesterol for 48 weeks to clarify the effects of long-term D-allulose consumption on cholesterol metabolism and efficacy.
Subjects were randomly assigned to 3 groups:
- high-dose D-allulose (15 g D-allulose/day)
- low-dose D-allulose (5 g D-allulose/day) and placebo group (0 g D-allulose/day).
Each subject consumed one test beverage daily for 48 weeks.
Clinical examinations were conducted every 8 weeks from the initial consumption to week 52.
No significant increases in T-Cho and LDL-C were observed between the test groups, and 48 weeks of D-allulose consumption did not alter the risk factors for atherosclerotic cardiovascular disease.
Furthermore, no clinical problems were observed for other parameters.
In addition, after long-term D-allulose consumption, significant improvements were observed in liver enzyme activity, fatty liver score, and glucose metabolism.
The results of our study showed that
1) D-allulose consumption can be considered safe for long-term intake, even for up to one year.
2) D-allulose may be effective in improving liver function and glucose metabolism.
