Which studies describe how allulose stimulates mitochondria to produce heat?
Allulose StoreStudies describing how allulose stimulates mitochondria to produce heat
The effect of allulose (D-allulose) on stimulating mitochondrial heat production and thermogenesis has been investigated by several studies, through different mechanisms.
The following sources available in the literature directly or indirectly describe this effect:
1. D-Allulose and Mitochondrial Energy Metabolism
• A 2021 study details how D-allulose activates the AMPK-SIRT1-PGC-1α signaling pathway, which is key in mitochondrial biogenesis and thermogenesis. Allulose increases PGC-1α protein expression and deacetylation, leading to increased heat production in brown and beige fat cells (adipocytes) 1 .
• The study found that allulose treatment also increased AMPK and SIRT1 activity in white adipose tissue, which promoted mitochondrial activity and thermogenesis. This mechanism contributes to the reduction of fat deposition and improved metabolism 1 .
2. Gene expression and metabolic studies
• Another study used gene expression analyses to show that allulose treatment restored genes related to mitochondrial energy utilization and electron transport that were downregulated by a high-fat diet. These results suggest that allulose improves mitochondrial function, promoting energy utilization and thermogenesis 2 3 .
• Research has shown that allulose treatment increased mitochondrial respiratory chain activity, ATP production, and fatty acid oxidation, all of which contribute to thermogenesis 3 .
3. Patent resources
• A patent specification also mentions that D-allulose can activate brown and beige fat cells, increasing cold-induced heat production, which is one of the most important signs of mitochondrial thermogenesis 4 5 .
Summary table
| Study/patent | Main finding | Source |
|---|---|---|
| D-allulose promotes deacetylation of PGC-1α via AMPK-SIRT1 axis | Allulose activates mitochondrial thermogenesis in adipocytes | 1 |
| Pathway Analysis of Allulose as a Sugar Substitute | Allulose improves mitochondrial energy metabolism, enhances electron transport | 2 3 |
| Brown/beige adipocyte activating agent containing d-allulose | Allulose activates brown/beige fat cells, increases heat production | 4 5 |
The most important scientific source that describes in detail the mechanism of mitochondrial thermogenesis under the influence of allulose:
• Lee GH et al., "D-allulose ameliorates adiposity through the AMPK-SIRT1-PGC-1α pathway in high-fat diet-induced obese rats" (Food & Nutrition Research, 2021) 1 .
This study details how allulose stimulates mitochondrial heat production through the AMPK-SIRT1-PGC-1α pathway.
Why are mitochondrial changes induced by allulose important for obesity and diabetes?
1. The role of mitochondrial function in metabolism
• Mitochondria the energy-producing centers of cells that are key in regulating fat and carbohydrate metabolism.
• Obesity and type 2 diabetes Mitochondrial dysfunction is often observed in patients with diabetes, which contributes to insulin resistance, fat accumulation, and inflammation 1 2 3 .
2. Effect of allulose on mitochondria
• Allulose, as a rare sugar, improves mitochondrial functions both in the liver and in fat cells, especially in obesity 4 .
• Allulose restores mitochondrial NADH homeostasis and protein synthesis, resulting in more efficient energy production and metabolic processes 4 .
• It has been shown that allulose mitochondrial uncoupling increases in adipose tissue, which may result in increased energy expenditure, heat production, and less fat deposition 5 .
3. Why is this significant for obesity and diabetes?
• In obesity Mitochondrial dysfunction reduces energy expenditure, promotes fat deposition, and increases insulin resistance 1 2 .
• Mitochondrial changes induced by allulose increase energy consumption and they improve insulin sensitivity , thus reducing body weight and improving blood sugar control 5 4 .
• Allulose It reduces inflammation and improves fat cell metabolism , which contributes to restoring metabolic health 4 .
4. Summary
The mitochondrial changes induced by allulose are important in obesity and diabetes because:
• Improves energy consumption and reduce fat deposition.
• Increase insulin sensitivity and improve glucose metabolism.
• Reduces inflammation and support healthy cell function.
These effects collectively contribute to weight loss and the reduction of the risk and symptoms of diabetes 5 4 1 .
